A widely available drug helps prevent upper gastrointestinal bleeding in critically ill adults on a breathing machine, according to the results of a global study and meta-analysis led by researchers at McMaster University.
McMaster UniversityJun 14 2024
Patients in the intensive care unit who need a breathing machine also receive pantoprazole to prevent upper gastrointestinal bleeding, caused by stress-induced ulcers in the stomach. Concerns emerged about whether this complication of critical illness had disappeared over the years, and about side effects of pantoprazole, including increased risk of death in the sickest patients. The research provides critical care teams with certainty about whether the medications should be used in practice.
Deborah Cook, lead author and principal investigator, professor in the Department of Medicine at McMaster Clinically important upper gastrointestinal bleeding occurred in 25 of 2,417 patients receiving pantoprazole and in 84 of 2404 patients receiving placebo. At 90 days, death was reported in 696 of 2390 patients in the pantoprazole group and in 734 of 2379 patients in the placebo group.
Breathing Gastroesophageal Reflux Disease Gastrointestinal Bleeding Heartburn Intensive Care Medicine Mortality Placebo Pneumonia Research Stress
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