GLP-1 receptor agonists and SGLT2 inhibitors, two classes of medications most commonly prescribed to treat Type 2 diabetes or weight loss, may reduce the risk of heart attack, second strokes and death in adults who had an initial stroke, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2024.
American Heart AssociationNov 11 2024 GLP-1 receptor agonists and SGLT2 inhibitors, two classes of medications most commonly prescribed to treat Type 2 diabetes or weight loss , may reduce the risk of heart attack , second strokes and death in adults who had an initial stroke, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2024. The meeting, Nov.
In this study, Sheffeh and colleagues evaluated whether two classes of medications for treating Type 2 diabetes are associated with a decreased risk of heart attacks, secondary stroke or death in stroke survivors. The other medication class, sodium-glucose cotransporter 2 inhibitors , lowers blood sugar levels by inducing the kidneys to remove excess glucose from the body through the urine. The SGLT2 medications canagliflozin, dapagliflozin, empagliflozin and ertugliflozin are approved by the FDA for the treatment of Type 2 diabetes.
The researchers also conducted a subanalysis of patients who took the medications for at least six months to confirm if the medications' association with a lower risk of heart attack, recurrent stroke and death could be attributed to the medications. The results were similar to those in the primary study: the medications were associated with lower risk of heart attack, recurrent stroke and death, Sheffeh noted.
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