The benefit-harm balance of initiating Glucagon-like Peptide-1 (GLP-1) receptor agonists (RAs) versus a placebo intervention.
By Priyanjana Pramanik, MSc.May 29 2024Reviewed by Lily Ramsey, LLM In a recent study published in eClinical Medicine , researchers investigated the benefit-harm balance of initiating Glucagon -like Peptide-1 receptor agonists versus a placebo intervention for weight loss among people living with obesity and overweight without diabetes.
Background GLP-1 RAs were initially approved to improve metabolic control in diabetes patients. Still, recent randomized control trials have shown their efficacy in weight reduction for non-diabetic adults, leading to approvals of drugs like semaglutide and liraglutide for weight management. The study compared liraglutide, semaglutide, and tirzepatide against a placebo, with all participants receiving lifestyle counseling to maintain a daily calorie deficit and engage in regular physical activity.
Preference weights were applied to adjust the benefit-harm balance, reflecting the relative importance of outcomes. Sensitivity analyses tested the robustness of results by varying assumptions about harm rates and preferences. GLP-1 RAs significantly increased the likelihood of achieving ≥5% and ≥10% weight loss compared to placebo, with relative risks of 2.51 and 4.11, respectively. Semaglutide had the highest efficacy for ≥10% weight loss , followed by tirzepatide and liraglutide .
The benefit-harm analysis showed a net benefit for achieving ≥10% weight loss over two years with GLP-1 RAs, particularly for semaglutide, which had a net benefit of 208 per 1000 people.
GLP-1 Obesity Receptor Weight Loss Alopecia Drugs Efficacy Glucagon Glucagon-Like Peptide-1 Medicine Placebo Semaglutide
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Treating obesity using glucagon-like peptide-1-directed N-methyl-D-aspartate receptor inhibitionBimodal drug that successfully cures obesity, hyperglycemia, and dyslipidemia in mouse models.
Read more »
Study finds GLP-1 receptor agonist use increases likelihood of antidepressant prescriptionIndividuals taking glucagon-like peptide (GLP)-1 receptor agonists have a greater risk for subsequently being dispensed antidepressants, according to a study published online April 23 in Diabetes, Obesity, and Metabolism.
Read more »
Peptide-based hydrogel shows promise for a wide range of tissue and organ repairCombining biomedical finesse and nature-inspired engineering, a uOttawa-led team of scientists has created a jelly-like material that shows great potential for on-the-spot repair to a remarkable range of damaged organs and tissues in the human body.
Read more »
Naturally-occurring peptide shows promise as new therapeutic in bone repairBirmingham researchers have shown that PEPITEM, a naturally-occurring peptide (small protein), holds promise as a new therapeutic for osteoporosis and other disorders that feature bone loss, with distinct advantages over existing drugs.
Read more »
These Rhode Peptide Lip Treatment dupes are almost exactly like the real thingObsessed with Hailey Bieber's Rhode Peptide Lip Treatment? We've found the very best dupes, starting at just £6. Read more on heat.
Read more »
Semaglutide may protect kidney function in individuals with overweight or obesity and cardiovascular diseaseThe SELECT Trial has revealed the potential of semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in combating kidney function decline among individuals with overweight or obesity and established cardiovascular disease but without diabetes.
Read more »