Glucose levels can affect processing speed and other cognitive functions, suggesting that minimizing glucose fluctuations is important for optimizing cognitive performance.
, according to a new study. It matters less whether glucose is considerably higher or lower than the patient's usual glucose level. Rather, cognition is slower when the glucose was atypical for that particular individual, with variations between different individuals.The investigators used continuous glucose monitoring digital sensors and smartphone-based cognitive tests to collect repeated, high-frequency glucose and cognitive data.
Using CGM and EMA, the researchers obtained "intensive" longitudinal measurements of glucose as well as cognition . Hierarchical Bayesian modeling estimated dynamic, within-person associations between glucose and cognition, and data-driven lasso regression identified identify clinical characteristics that predicted differences from person to person in cognitive vulnerability to glucose fluctuations.Cognitive performance was reduced both at low and high glucose levels, "reflecting vulnerability to glucose fluctuations.
Large glucose fluctuations were associated with slower as well as less accurate processing speed, although slight glucose elevations were associated with faster processing speed, regardless of the absolute level of those means.
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