Osteoporosis is a skeletal condition that leads to the weakening of bones, making them porous, fragile, and prone to breakage.
Tokyo University of ScienceJun 18 2024 A whopping 8.9 million fractures are caused by osteoporosis annually, with one fracture occurring every three seconds! The aging population is the most vulnerable to primary osteoporosis, given, their frailty, and often, requires long-term therapy and support. Advances in healthcare and the corresponding rise in the aging population have put a strain on available resources, underscoring the need for effective therapies against osteoporosis.
To bridge this gap, Professor Tadayoshi Hayata and Ms. Chisato Sampei, from Tokyo University of Science, along with their colleagues, conducted a series of experiments to identify druggable target genes downstream of PTH signaling in osteoblasts. Explaining the rationale behind their study published on 20 May, 2024, in the Journal of Cellular Physiology, corresponding author, Prof. Hayata says, "In Japan, it is estimated that 12.
PTH induction has been known to activate the cyclic adenosine monophosphate and protein kinase C signaling pathways. Interestingly, the team found that in addition to PTH induction, activation of cAMP and PKC also resulted in overexpression of Gprc5a, albeit to a lesser extent, underscoring the potential involvement of other molecular pathways.
Related StoriesDiving deeper into the molecular mechanisms underlying the effects of Gprc5a, in PTH-induced osteogenesis, the researchers identified Activin receptor-like kinase 3 – a bone morphogenetic protein signaling pathway receptor, as an interacting partner of Gprc5a. In line with their speculation, overexpression of Gprc5a indeed, led to suppression of BMP signaling via receptors including ALK3.
Aging Bone Camp Cell Fracture Gene Genes Healthcare Hormone Kinase Osteoblast Osteoclast Pharmacology Physiology Proliferation Protein Receptor Research Teriparatide
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