Science, Space and Technology News 2024
The new study demonstrates the structural basis of the interaction between cancer-promoting proteins MAGEA4 and RAD18 . Credit: Isabel Romero Calvo/EMBL
The Melanoma Antigen Gene family consists of more than 40 proteins in humans, most of which are only present in the testes under healthy conditions. However, in many cancers, these proteins are found in high levels in tissues where they are not usually expressed and are believed to play a role in promoting cancer progression.
Interestingly, the researchers could use a short synthetic protein fragment, mimicking the part of RAD18 that binds the groove in MAGEA4, to block the interaction between the two proteins. This could potentially pave the way for the design of drugs that target this complex and prevent RAD18 build-up within cancer cells.
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