Growth factor study reveals potential breakthrough in obesity management Nature obesity obesitymanagement growthfactor GDF15
By Dr. Liji Thomas, MDJul 4 2023Reviewed by Lily Ramsey, LLM An 'obesity epidemic' is affecting the world. Medical, surgical, exercise-related, and dietary measures are all being marketed worldwide to prevent or reduce this condition.
It also improves the sensitivity of the peripheral tissues, especially skeletal muscle, to the hormone insulin that promotes glucose uptake and utilization, thus reducing the glucose levels in the blood. GDF15 led to weight loss in such rodents and reduced non-alcoholic fatty liver disease while normalizing blood glucose levels.
The short period of most rodent studies precludes the ability to pick up such changes, which occur after caloric restriction of a longer duration. Again, mice kept at room temperature, that is, at 21 °C, are below their preferred temperature , driving sympathetic responses. This could prevent weight loss from occurring in response to β-adrenergic-dependent agents.
Mice were treated with GDF15 at the beginning of the light and dark cycles. Mice eat most during the dark cycle. In the former case, their food intake was reduced by a third, but by almost half in the latter, consonant with the difference in food intake under normal conditions in these two phases. In the other two treatment groups, treated and control pair-fed mice showed the same weight loss trends for the first ten days. Following this period, body mass loss evened out in pair-fed mice.
The results also showed that the rodents ate less, but still used up energy as usual, thus promoting weight loss. This occurred irrespective of housing temperature, but more energy was expended at the lower temperature.
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