Researchers have discovered a link between gut bacteria and the success of milk-allergy oral immunotherapy. The study found that Bifidobacterium -- a genus of beneficial bacteria in the gut -- was associated with a higher chance of successful treatment.
The finding may help in the development of more effective oral immunotherapies, perhaps by combining them with probiotic supplements.
Gut bacteria are thought to help reduce allergic reactions to some foods, but little is known about the link between these bacteria and oral immunotherapy for milk allergy. Therefore, the RIKEN IMS team examined 32 children with cow's milk allergy who received oral immunotherapy, with the first month being conducted in a hospital."Oral immunotherapy is not without risk," explains Ohno.
To understand why the treatment worked for these seven children but not the others, the team looked for the clinical factors and types of gut bacteria that were related to successful treatment. Of the clinical factors, unsuccessful treatment was more likely in children who were being treated for eczema or asthma and in children who initially had higher levels of milk-protein antibodies. Among the gut bacteria, the presence offamily was related to a higher chance of successful treatment.
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