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A 2023 study adds further support to the theory that inflammation could be the mechanism through which this occurs.when the research was published,"and among people with Alzheimer's, when we looked at brain imaging, those with higher gut inflammation had higher levels of amyloid plaque accumulation in their brains."Participants underwent several cognitive tests on enrollment, as well as interviews on family history and tests for a high-risk Alzheimer's gene.
Levels of other Alzheimer's disease biomarkers also increased with levels of inflammation, and memory test scores dropped with higher calprotectin too. Even the participants without a diagnosis of Alzheimer's had poorer memory scores with higher levels of calprotectin.Heston and colleagues suspect microbiome changes trigger gut changes that lead to system-wide inflammation.
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