Harvard researchers have mapped and catalogued more than 70,000 synaptic connections from about 2,000 rat neurons, using a silicon chip capable of recording small yet telltale synaptic signals from a large number of neurons.
Harvard John A. Paulson School of Engineering and Applied SciencesFeb 14 2025
While electron microscopy has been used with great success to make visual maps of synaptic connections, these images lack information on connection strengths and thus the ultimate function of the neuronal network. The researchers, led by Donhee Ham, the John A. and Elizabeth S. Armstrong Professor of Engineering and Applied Sciences at the Harvard John A. Paulson School of Engineering and Applied Sciences , developed an array of 4,096 microhole electrodes on a silicon chip, which performed massively parallel intracellular recording of rat neurons cultured on the chip.
They operated the chip to gently open up cells with small current injections through the electrodes in order to parallelize their intracellular recording. Postdoctoral researcher Wang said the microhole design is similar to the patch-clamp electrode, which is essentially an electrode-housing glass pipette with a hole at the end.
CHIP Electrode Electron Electron Microscopy Intracellular Microscopy Neuron Neurons Research Technology
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