Both very high and very low levels of high-density lipoprotein cholesterol were associated with an increased risk for diabetic kidney disease in women, but not men, with T2D.
Very high and very low levels of high-density lipoprotein cholesterol are linked to a higher risk for kidney disease in women with type 2 diabetes , but not in men.Studies have reported a strong association between low HDL-C levels and the risk for diabetic kidney disease , but whether higher HDL-C levels can influence the risk for diabetic kidney disease remains unclear.
Researchers conducted a cross-sectional observational study of 936 patients with T2D , from the Endocrinology Department at the Jinhua Hospital between September 2020 and July 2021. To examine the relationship between HDL-C levels and the risk for diabetic kidney disease, researchers used logistic regression to assess the continuous and categorical associations and a restricted cubic spline curve to assess the nonlinear association.
HDL-C levels were categorized into four groups, with 0.40-0.96 mmol/L corresponding to the lowest quartile and 1.32-6.27 mmol/L corresponding to the highest quartile.The risk for diabetic kidney disease was higher when the HDL-C levels were 1.54 mmol/L. Compared with patients with HDL-C levels in the range of 0.95-1.54 mmol/L, those with very high and very low HDL-C levels had a 128% and 77% increased risk for diabetic kidney disease, respectively. "Although HDL-C is generally considered a cardiovascular protective factor, at very high levels, this protective effect does not seem to hold true and may be associated with an increased DKD risk," the authors wrote.
Diabetes Mellitus Type Ii Type 2 Diabetes Type 2 DM T2DM T2D Renal Disease Kidney Disease Kidney Disorder Renal Disorder Nephropathy Kidneys Lipids Lipid Management High-Density Lipoprotein Cholesterol Hdl-C Hdl Hdl Cholesterol Lipoproteins Hospitals
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Atrial Fibrillation Linked to Dementia in T2DNew-onset atrial fibrillation is an independent risk factor for all-cause dementia in patients with T2D, who are more prone to both conditions, says UK Biobank data analysis.
Read more »
Postdoctoral Associate- Cholesterol and Intestinal Stem Cells - Houston, Texas (US) job with Baylor College of Medicine (BCM)The Lagor laboratory is seeking a postdoctoral fellow to study the physiological regulation of cholesterol synthesis in the intestine. The project has two main goals- to determine how cholesterol synthesis controls intestinal stem cell proliferation, and to determine how newly synthesize cholesterol impacts cholesterol excretion.
Read more »
Cholesterol, triglycerides, and nutrition: How your diet may increase your cancer oddsMetabolic diseases such as hypertension or diabetes can elicit an inflammatory response that damages a person's DNA, which over time may cause normal cells to become cancerous.
Read more »
5 swaps for butter that can improve cholesterol, lower heart disease risksStart spreadin’ the news.
Read more »
New PCSK9s Nearing Market Will Help Meet Cholesterol TargetsDifferent formulations and dosing schedules are expected to help many more patients reach LDL goals.
Read more »
'A serious weather event is coming' | Texas increases readiness level ahead of Tropical Storm BerylBeryl's forecast cone includes much of Texas, with impacts possible early next week.
Read more »