A study in The American Journal of Clinical Nutrition shows that hemp seed protein and its bioactive peptide can significantly lower blood pressure in mildly hypertensive adults, offering a potential dietary intervention for managing hypertension.
By Dr. Sanchari Sinha Dutta, Ph.D.May 7 2024Reviewed by Benedette Cuffari, M.Sc. In a recent study published in The American Journal of Clinical Nutrition , researchers investigate the efficacy of hemp seed protein and its bioactive peptide in managing blood pressure in mildly hypertensive individuals.
Blood pressure in humans is primarily regulated by the renin-angiotensin-aldosterone system . Within RAS, the angiotensin-converting enzyme catalyzes the conversion of angiotensin I to angiotensin II, a vasoconstrictor responsible for reducing blood flow. Comparatively, nitric oxide produced in the vascular endothelium by endothelial NO synthase acts as a vasodilator, leading to reduced vascular tone and induction of blood flow.
Hemp seed is a plant-based protein source rich in amino acids with blood pressure-lowering properties. Bioactive peptides derived from hemp seed protein hydrolysates have been found to reduce systolic blood pressure and inhibit ACE activity in animals. The dietary interventions were followed for six weeks, along with a two-week washout period. Fasting blood samples were collected from the study participants at six time points to measure blood pressure biomarkers, including ACE, renin, and NO.
Effect of dietary interventions on blood pressure The analysis of 24-hour blood pressure levels revealed that the hemp seed protein-derived bioactive peptide and casein had the highest and lowest blood-pressure-lowering effects, respectively. More specifically, the hydrolysate-derived bioactive peptide reduced systolic and diastolic blood pressure by 8.9 mmHg and 5.8 mmHg, respectively. A reduction of 3.5 and 2.
Aldosterone Angiotensin Bioactive Peptide Blood Blood Pressure Chronic Efficacy Enzyme Nitric Oxide Nutrition Renin Vascular
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