This product profile highlights HER3 (ERBB3), a crucial member of the Epidermal Growth Factor Receptor (EGFR) family, implicated in key cellular processes such as proliferation, survival, and differentiation through the PI3K/Akt, MAPK, and JAK/STAT signaling pathways.
is a crucial member of the Epidermal Growth Factor Receptor family. It plays a significant role in cellular proliferation, survival, and differentiation via the PI3K/Akt, MAPK, and JAK/STAT signaling pathways. Even though HER3 signaling is essential for tissue growth and homeostasis, dysregulation of this signaling pathway is linked to the advancement of cancer, making it a potentially effective therapeutic target for several cancers.
Under typical physiological circumstances, HER3 plays a role in tissue growth and homeostasis. On the other hand, dysregulation of HER3 signaling has been linked to several cancers, including those of the breast, ovaries, prostate, and stomach. The distinctive characteristic of HER3 is its strong ability to form heterodimers with other members of the ERBB family, especially HER2, which can result in increased oncogenic signaling and resistance to treatment.
Epidermal Growth Factor Receptor (EGFR) Cancer Immunotherapy
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