Researchers compare the effectiveness and acceptability of oral monotherapy with psychedelics for the treatment of depressive symptoms.
By Vijay Kumar MalesuReviewed by Benedette Cuffari, M.Sc.Aug 27 2024 Study: Comparative oral monotherapy of psilocybin, lysergic acid diethylamide, 3,4-methylenedioxymethamphetamine, ayahuasca, and escitalopram for depressive symptoms: systematic review and Bayesian network meta-analysis. Image Credit: YAR Photographer / Shutterstock.com
Further research is needed to accurately determine the true efficacy of psychedelics, as current trials may be biased by compromised blinding and the influence of psychological support. The authors independently conducted data extraction and risk of bias assessment, resolving any discrepancies through discussion. Bayesian network meta-analysis was used to estimate relative effects between interventions, with sensitivity analyses addressing potential effect-modifying factors.
Taken together, these studies comprised 15 trials involving 811 participants in psychedelic trials with an average age of 42.5 years, 54.2% of whom were women. Additionally, 1,968 participants were involved in escitalopram trials, whose average age was 39.4 years, 62.5% of whom were women.
Antidepressant Efficacy Placebo Research
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