High maternal linoleic acid intake during pregnancy may impact fetal development and increase the risk of obesity and inflammation in offspring. However, more research is needed to fully understand these effects in humans.
Sep 10 2024 New research reveals potential dangers of common dietary fats during pregnancy, highlighting the need for balanced nutrition to protect future generations.
A balanced diet is necessary to support healthy placental development, fetal needs, and the increased requirements related to maternal adaptation to pregnancy. LA levels in the diet have substantially increased in Westernized regions. Since ALA and LA are metabolized by the same enzymes, increased intake of LA reduces ALA conversion to DHA and EPA. The optimal dietary LA-to-ALA ratio of 1:1 or 2:1 has increased manifold, now ranging between 4:1 and 20:1. This interference in the production of DHA and EPA is significant because DHA and EPA are critical for cardiovascular health and reducing inflammation.
Higher maternal intake of LA reduced plasma levels of leptin in rodents. In addition, altering dietary intake of LA between 1% and 8% of total energy showed varying effects on adiponectin and leptin in pregnant mice, suggesting a complex interaction that needs further exploration, particularly in human studies.
Further, increased LA intake in pregnancy has been associated with shorter infant femur lengths. One study found that higher dietary intake of ALA and LA in the third trimester of pregnancy increased birth length.
Obesity Pregnancy Arachidonic Acid Birth Weight Blood Brain Cell Cell Membrane Childhood Obesity Chronic Diet Docosahexaenoic Acid Endocannabinoids Fatty Acids Glucose Glucose Metabolism Inflammation Leptin Membrane Metabolism Nutrients Nutrition Placenta Vitamins
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