Healthy blood vessels matter for more than just heart health. Vascular well-being is critical for brain health and potentially in addressing age-related cognitive decline and neurodegenerative disorders, like Alzheimer's disease, according to new study led by Penn State researchers.
The Pennsylvania State UniversityJul 31 2024 Healthy blood vessels matter for more than just heart health. Vascular well-being is critical for brain health and potentially in addressing age-related cognitive decline and neurodegenerative disorders, like Alzheimer's disease, according to a new study led by Penn State researchers.
Blood vessels, especially micro-vessels, regulate oxygen and energy supply and waste removal to and from neurons. Despite their importance, Kim said, most existing research focuses on how neuron structure and function degenerates over time, rather than the vasculature. When researchers do study the brain's vasculature, they've primarily examined larger blood vessels or focused on a single, easy-to-access region of the brain, the somatosensory cortex.
The images showed that changes in the vascular network don't occur equally across the brain. Rather, they were concentrated in the basal forebrain, deep cortical layers and hippocampal network, suggesting these areas are more vulnerable to vascular degeneration. These regions play a role in attention, sleep, memory processing and storage, among other functions.
Blood Vessels Brain Aging Alzheimer's Disease Cell Cell Death Dementia Heart Imaging Imaging Techniques Nerve Neurodegenerative Disease Neurons Research Sleep Vascular Vasculature
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