A systematic review published in Crit_Care finds that targeting a higher mean arterial pressure in shock or perioperative patients may not be superior to normotension in terms of preventing acute kidney injury.
] criteria or other equivalent definitions) or rates of renal replacement therapy receipt. For outcomes reported at multiple timepoints, we used the furthest reported follow-up timepoint but capped at 30-day timepoints. We excluded studies that met any of the following criteria: animal research and pediatrics or obstetrics research.
We assessed risk of bias independently using Cochrane RoB updated version for which each domain is rated as “low risk”, “high risk”, or “some concerns”. We assessed RoB-2 according to intention-to-treat basis, based on one main outcome of interest reported in the studies: AKI rates and RRT receipt rates, respectively.
We assessed the certainty of the body of evidence for each outcome by the Grading Recommendations Assessment, Development and Evaluation approach. We used the Guideline Development Tool to formulate the Summary of Findings table. Any disagreements regarding RoB or GRADE assessment were resolved by consensus.Normotensive levels were determined according to the common “lower” MAP intervals across the patient populations.
We assessed heterogeneity between trials by visual inspection of the forest plots, the chi-squared test for homogeneity , and the
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