A new study reveals hormonal and biochemical factors that affect alcohol dependence (also known as Alcohol Use Disorder), suggesting that men and women with alcohol problems may benefit from different treatments.
European College of NeuropsychopharmacologySep 22 2024 A new study reveals hormonal and biochemical factors that affect alcohol dependence , suggesting that men and women with alcohol problems may benefit from different treatments.
"This is the first large study to confirm that some of the variability in Alcohol Use Disorder and related problems is associated with particular combinations of hormones and chemical biomarkers in men and in women. It may mean that sex-specific treatments can be tailored to improve responses for men and women with alcohol problems" said lead researcher Victor Karpyak, Professor of Psychiatry at Mayo Clinic in Rochester, Minnesota .
At the beginning of the trial – before anyone had taken any medication – the researchers tested men and women for several sex-specific blood markers, including sex hormones as well as proteins known to impact their reproduction or bioavailability of these hormones in the blood . We found that there were different associations in men and women. For example, women who had higher levels of testosterone, sex hormone binding globulin, and albumin were also more likely to relapse during the first three months of treatment compared to women with lower levels of those biochemical markers. No such relationships were found in men.
Albumin Alcohol Dependence Blood Hormone Protein Psychiatry Research Testosterone
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