Rapamycin, a drug for transplant patients, has extended the lives of animals but is unproven in humans. That hasn’t stopped people from trying it.
To keep himself healthy into his eighth decade, David Sandler recently decided to go beyond his regular workouts and try something experimental: taking rapamycin, an unproven but increasingly popular drug to promote longevity.
Despite the buzz surrounding the drug, it is unlikely that the Food and Drug Administration will ever approve it for longevity. “Mice may be a little different from humans when it comes to drug tolerance, diseases and reactions,” said Elena Volpi, a professor and longevity expert at the University of Texas Health Science Center at San Antonio.
“At 60, I don’t have the luxury of expecting studies to be completed that can validate the benefits of a longevity drug prior to my own steeper decline,” said Rosen, who also has prescribed the drug to about 250 patients. The promising animal studies, combined with rapamycin’s long history as an immune-suppressing drug, he said, makes it “one of few agents where taking a calculated risk can absolutely make sense.”is pledging to spend up to $1 billion a year to accelerate research on aging.
“I don’t know yet what’s the right dose, what’s the right duration, what are the risks, what are the benefits,” said Mannick. Now chief executive of Tornado Therapeutics, she is aiming to develop athat could be even more effective — and patentable. “I think we’ll be able to get there, but we aren’t there yet.”Others are not inclined to wait. “Get Rapamycin online,” AgelessRx, a longevity-focused telehealth firm, advertises on Google.
Attia, who has a medical practice focused on helping people live longer and healthier, dedicates a chapter of his 2023 book to rapamycin and has said he takes the drug himself. With more than 600,000 subscribers to his, Attia has become one of the most influential voices in longevity medicine, and many doctors say patients learn about rapamycin from him.
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