Older hospitalized adults with both magnesium and calcium deficiencies exhibit significantly lower cognitive function, highlighting the need for nutrient monitoring in aging populations.
By Dr. Sanchari Sinha Dutta, Ph.D.Reviewed by Benedette Cuffari, M.Sc.Nov 4 2024 Insufficient magnesium and calcium levels may speed up cognitive decline in older adults, with potential insights into preventing memory loss and supporting brain health through nutrient balance.
Cognitive decline is a typical characteristic feature in older adults that is associated with calcium and magnesium deficiencies. The risk of magnesium and calcium deficiencies increases with age due to reduced dietary intake, impaired absorption, and chronic diseases. Several studies have reported that higher dietary intake of calcium and magnesium is associated with better cognitive performance in older adults.
Important observations The highest cognitive test scores were observed in participants with normal serum calcium and magnesium levels, followed by participants with hypomagnesemia, hypocalcemia, and both hypomagnesemia and hypocalcemia. Participants with hypocalcemia or both hypocalcemia and hypomagnesemia exhibited significantly lower scores in both cognitive tests than individuals with normal calcium and magnesium levels or hypomagnesemia.
The study participants with dementia, as defined by MMSE scores below 24, exhibited significantly lower serum levels of both calcium and magnesium. Similarly, participants with poor cognitive performance, as determined by CDT scores below five, exhibited substantially lower calcium levels.
Magnesium Adenosine Adenosine Triphosphate Brain Cell Cholesterol Chronic Cognitive Function Dementia Hypocalcemia Hypomagnesemia Inflammation Nervous System Nutrients Oxidative Stress Stress
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