Interoception research reveals how gut-brain communication via neural, hormonal, and microbial pathways regulates metabolism, hunger, and overall health, offering insights for therapeutic innovations.
By Vijay Kumar MalesuReviewed by Susha Cheriyedath, M.Sc.Nov 25 2024 Unveiling the science of gut-brain signals: How neural and hormonal pathways shape metabolism, behavior, and groundbreaking therapies for health challenges.In a recent review published in the journal Current Biology, researchers examined the origins, mechanisms, and significance of interoception and gut-brain communication in homeostasis, emphasizing neural and hormonal pathways influencing feeding behavior and metabolism.
Emergence of Interoception in Modern Science The term "interoceptive", coined in the early 20th century, described internal sensory receptors. However, research on interoception gained momentum in the mid-20th century through biofeedback therapy for managing metabolic and psychiatric disorders. For instance, experiments severing gut-brain connections in flies and mammals demonstrated impaired metabolic and behavioral regulation. Such findings emphasize the conserved nature of gut-brain pathways throughout evolution.
Recent findings suggest that microbiota-derived metabolites may modulate higher brain functions, including mood and cognition, opening new avenues for research.
Metabolism Diabetes Digestion Food Ghrelin GLP-1 Glucose Gut-Brain Axis Mental Health Metabolites Nerve Nervous System Neurodegenerative Diseases Neurons Obesity Research Stress
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