Researchers investigate the effects of perceived stress on sperm motility and maturation.
By Dr. Sushama R. Chaphalkar, PhD.Reviewed by Benedette Cuffari, M.Sc.Sep 16 2024 New study reveals how stress boosts sperm motility through mitochondrial changes and epigenetic shifts. Study: Stress increases sperm respiration and motility in mice and men. Image Credit: Rost9 / Shutterstock.com
Stress and fertility Stress influences long-term reproductive fitness; however, the underlying cellular and molecular mechanisms responsible for the impact of stress on fertility remain unclear. Evidence suggests that prolonged stress induces allostasis, a process where stress-induced changes in cellular function persist after the stress ends.
About the study A total of 34 healthy males between 18 and 35 years of age were recruited from the University of Colorado and Denver Metropolitan area using social media and flyers. Study participants were screened for medical history and excluded based on specific criteria, including psychotropic medication use, substance abuse, and sperm abnormalities.
Cleavage Under Targets and Release Using Nuclease and ribonucleic acid isolation were performed to study gene expression and chromatin modifications. Respirometry was conducted to assess oxygen consumption rates in DC2 cells and sperm. Study findings Sperm volume, concentration, and motility did not change significantly in humans. PSS at three months prior to sperm collection was positively associated with average path velocity , curvilinear velocity , and straight line velocity . Higher PSS at this time point correlated with increased sperm motility metrics, whereas PSS at the time of collection and previous two months were not significantly different.
Changes in GR localization were observed, along with reduced nuclear GR, increased mitochondrial GR, and altered sperm respiration. Substrate injection indicated reduced respiration for complex I substrates in post-corticosterone EECs.
Stress Corticosterone Fertility Gene Genes In Vitro Research Semen
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