How to repair a damaged heart: Key mechanism behind heart regeneration in zebrafish revealed _Hubrecht sciencemagazine
and applying these discoveries to human heart muscle cells could contribute to the development of new therapies against cardiovascular diseases.
Live imaging of calcium movements through lab grown human heart muscle cells . Credit: Phong Nguyen and Giulia Campostrini, copyright: Hubrecht InstituteUnlike humans, some species like zebrafish can regenerate their hearts. Within 90 days after damage, they fully restore their cardiac function. The surviving heart muscle cells are able to divide and produce more cells. This unique feature provides zebrafish hearts with a source of new tissue to replace the lost heart muscle cells.
"The calcium movement in the newly divided cell was initially very similar to embryonic heart muscle cells, but over time the heart muscle cells assumed a mature type of calcium movement. We found that the cardiac dyad, a structure that helped to move calcium within the heart muscle cell, and specifically one of its components, LRRC10, was crucial in deciding whether heart muscle cells divide or progress through maturation.
Strikingly, LRRC10 changed the calcium handling, reduced cell division and increased the maturation of these cells in a similar manner as observed in zebrafish hearts. Nguyen says,"It was exciting to see that the lessons learned from the zebrafish were translatable as this opens new possibilities for the use of LRRC10 in the context of new therapies for patients.
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