A study has shown that traumatic experiences during childhood may get 'under the skin' later in life, impairing the muscle function of people as they age.
A study has shown that traumatic experiences during childhood may get 'under the skin' later in life, impairing the muscle function of people as they age.
The researchers examined muscle biopsies to determine two key features of muscular function: the production of adenosine triphosphate, or ATP, and another measure called oxidative phosphorylation, a process that helps produce ATP. Produced by organelles within cells called mitochondria, ATP provides the chemical energy to fuel cellular function.
"What these results suggest is that these early formative childhood experiences have the ability to get under the skin and influence skeletal muscle mitochondria, which is important because mitochondrial function is related to a host of aging-related outcomes," Duchowny said."If you have compromised mitochondrial function, that doesn't bode well for a range of health outcomes, including everything from chronic conditions to physical function and disability limitations.
"You can think about oxygen consumption rate as a way to measure the flow of electrons that's going through the electron transport train, and it's these electrons that generate the membrane potential that drives the synthesis of ATP," Molina said."It's a really precise way of assessing mitochondrial bioenergetic capacity."
"All of my previous studies have been focused on contemporaneous measures: mitochondria and physical function, mitochondria and cognitive function," Molina said."These studies have shown that these measures are strongly related to our strength, fitness and numerous conditions that impact physical ability.
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