How two different types of immunecells help two billion people keep tuberculosis in check natimmunol
in the lungs that contain the infection. These granulomas contain B cells, all-purpose immune cells that perform a variety of functions, from producing antibodies to regulating the activity of other cells. For years, researchers assumed that these B cells must be performing a specific direct function in the granulomas to control TB infection, but in a new study, scientists from the University of Chicago and Washington University in St.
In addition to the results in mice, the team saw the same results when they completely deleted B cells in non-human primate models. As Khader and her team narrowed down the potential functions of the B cells, they saw that the helper T cells express transcription factors that in turn generate T cell subtypes, including T follicular helper -like cells that localize within the granuloma tissue. It is these Tfh-like cells that activate macrophages to keep the TB infection in check by surrounding and killing infected cells, but the B cells tell them where to go and localize within the granulomas.
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