Dietary niacin intake reduces risks of all-cause and cardiovascular mortality in US adults, with benefits more pronounced in non-diabetic individuals and linked to NAD metabolism improvements.
By Dr. Sanchari Sinha Dutta, Ph.D.Nov 18 2024 Discover how a key nutrient in your diet could hold the secret to a longer life and better heart health with groundbreaking insights into niacin’s role in metabolic and cellular rejuvenation.
Niacin-rich foods include tuna, salmon, turkey, peanuts, and fortified packaged products, providing a convenient dietary source of vitamin B3. Studies have produced mixed results regarding the cardioprotective effects of niacin. This phenomenon, known as the "niacin paradox," highlights cases where lipid profile improvements do not consistently lead to better cardiovascular outcomes. While some studies have found moderately beneficial effects of niacin on cardiovascular events, some have found that niacin does not reduce cardiovascular event risks and that it may increase the risk of all-cause mortality.
Statistical analyses were carried out to compare the risk of all-cause and cardiovascular mortality among participants grouped into different dietary niacin intake quartiles. Sensitivity analyses, such as excluding participants with pre-existing cardiovascular disease or cancer, confirmed the robustness of these findings.
Niacin supplements, while beneficial, can cause side effects such as skin flushing and, in excessive doses, liver toxicity or hyperglycemia, emphasizing the need for supervised use.
Alcohol Blood Cancer Cardiovascular Disease Cell Cholesterol Coffee Dementia Dermatitis Diabetes Diarrhea Diet Dyslipidemia Lipoprotein Metabolism Mortality Muscle Niacin Nutrition Research Smoking Tea Wheat
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