Advancements in organoid technology are crucial for Parkinson's disease research, providing human-relevant models for studying disease and testing therapies.
By Vijay Kumar MalesuReviewed by Lily Ramsey, LLMOct 23 2024 Scientists are leveraging cutting-edge organoid technology to uncover the causes of Parkinson's and accelerate the development of new treatments.
The loss of midbrain dopaminergic neurons and the presence of Lewy Bodies, made of abnormal α-synuclein protein, are hallmarks of PD. Current research tools, including post-mortem brain tissue, animal models, and cell cultures, have limitations. This technology has been particularly useful in modeling various parts of the brain, including the forebrain, midbrain, and hippocampus. Brain organoids have become instrumental in studying neurodevelopment and recapitulating human diseases, such as PD.
Further advancements over the next few years led to protocols that allowed for the long-term maintenance and maturation of these organoids. Predicting PD toxicity Toxin-based models of PD have been developed using hMLOs to study how environmental toxins contribute to the disease. Two prominent examples are the use of neurotoxins 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-Hydroxydopamine .
Developing treatments for PD The therapeutic potential of hMLOs is immense. One promising application involves the generation of neural stem cells from midbrain organoids. These NSCs can differentiate into mDA neurons, which are crucial for PD treatment.
Parkinson's Disease Bradykinesia Brain Cell Depression Disease Modeling Dopaminergic Drugs In Vitro Lewy Bodies Movement Disorder Neurodegenerative Disorder Neuron Neurons Oxidative Stress Protein Research Stem Cells Stress Technology
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