Hyperuricemia Subtypes in Gout Show Distinct Clinical, Genetic Features

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Hyperuricemia Subtypes in Gout Show Distinct Clinical, Genetic Features
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  • 📰 Medscape
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The distinct biologic features of different hyperuricemia subtypes call for the development of tailored, subtype-dependent, genetics-based therapies for gout or hyperuricemia.

Hyperuricemia, a universal condition in patients with gout, can be classified into four subtypes on the basis of the urinary uric acid excretion values; however, the unique biologic traits of each subtype have not yet been thoroughly investigated.

The hyperuricemia subtypes were defined as renal uric acid overload , renal underexcretion , combined, or renal normal subtypes on the basis of both 24-hour urinary uric acid excretion and uric acid fractional excretion values.

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