For patients with atrial fibrillation undergoing left atrial appendage occlusion (LAAO), high-grade hypoattenuation thickening (HAT) at follow-up computed tomography (CT) is associated with higher stroke risk, according to a study published online Sept. 5 in Radiology.
The researchers found that low- and high-grade HAT were depicted in 23.8% and 5.1% of participants, respectively. Higher odds of antithrombotic drug discontinuation during follow-up were seen in association with high-grade HAT , while low-grade HAT was associated with reduced odds of persisting left atrial appendage patency . Stroke occurred in 5.8% of participants during a median follow-up of 17 months; high-grade HAT was associated with stroke , but no association was seen for low-grade HAT.
"These findings support the introduction of unequivocal standardized CT criteria for HAT grading, with important implications for treatment regimen optimization after implantation," the authors write.Xavier Iriart et al, Clinical Implications of CT-detected Hypoattenuation Thickening on Left Atrial Appendage Occlusion Devices,
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