University of Chicago researchers use advanced imaging techniques to study the structure of aGPCRs, offering new insights into how these important proteins function and paving the way for potential new drug development.
University of Chicago researchers have made a breakthrough in understanding adhesion G protein-coupled receptors (aGPCRs), a large family of proteins crucial for cell communication and many bodily functions. aGPCRs are involved in tissue growth, immune system function, and organ formation. Problems with these receptors can lead to diseases like cancer, brain disorders, and growth issues.
Despite their importance, no drugs have been approved to target aGPCRs because they are complex and difficult to study. The new research combines two powerful imaging techniques to reveal the complete structure of a common aGPCR, including how its long extracellular region interacts with the transmembrane region embedded in the cell surface. The study found that the different positions and movements of the extracellular region appear to be an important way to activate the receptor. This discovery opens up new opportunities for developing drugs that target aGPCRs
Agpcrs Cell Communication Drug Development Medical Research Protein Structure
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