Insights from advanced imaging technology show how neurons communicate at the atomic level for the first time.
For the first time, scientists at The Hospital for Sick Children used advanced imaging technology at the SickKids Nanoscale Biomedical Imaging Facility to reveal the atomic structure of an enzyme that neurons use to communicate.
On the publication of these findings, Rubinstein shares how his team captured the images, and what their findings could mean for patients in the future.When communicating, neurons release neurotransmitters into a synapse to be delivered to a receiving neuron. These neurotransmitters are released from small packets called synaptic vesicles.
We created 3D models of the V-ATPase based on images we captured using cryogenic electron microscopy , a method that images samples at -196 C. Our team saw that V-ATPase interacts with several components of the synaptic vesicle, which contains many proteins and lipids that are involved in neurotransmitter release.
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