Impact of age-related alterations in lipid metabolism on general health Nutrients_MDPI lipidmetabolism generalhealth lipid metabolism research aging health
By Dr. Sanchari Sinha Dutta, Ph.D.Aug 8 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in Nutrients, scientists provide a detailed overview on age-related alterations in lipid metabolism and its association with age-related chronic diseases.
In the elderly, hyperlipidemia and visceral fat accumulation increase the risk of many chronic diseases including cardiovascular disease, type 2 diabetes, obesity, and nonalcoholic fatty liver disease. Related StoriesAmong lipid digestive enzymes, gastric lipase is primarily responsible for lipid breakdown in the GI tract; however, the activity of this enzyme negatively correlates with age. Lipase remains stable in acidic pH; however, age-related gastric atrophy and the chronic use of acid suppressive medicines collectively reduce gastric acid secretions, which may contribute to reduced activity of gastric lipase in elderly people.
The exact changes in lipid absorption in elder people remain largely unknown. Previous research suggests reduced triglyceride absorption and an induction in cholesterol absorption with age.
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