Researchers have discovered the connection between aldehydes, organic compounds produced by cells as part of metabolic processes, and rapid aging.
Their findings indicate a potential treatment for diseases that lead to accelerated aging as well as a means to counteract aging in healthy people by controlling exposure to aldehyde-inducing substances including alcohol, pollution, and smoke.
"DNA damage is linked with aging phenotypes," said Oka."However, for the first time, we propose a relationship between aldehyde-derived DNA damage and premature aging." Aldehydes are harmful because they are highly reactive with DNA and proteins. In the body, they form DNA-protein crosslinks that block important enzymes in typical cell proliferation and maintenance processes, causing these processes to malfunction and the patient to age.
Professor Ogi is hopeful about the implications of their findings, stating:"By elucidating the mechanism by which DNA damage heals quickly, we have revealed part of the cause of genetic premature aging." This research has implications that extend beyond genetic diseases, as their findings suggest that aldehyde-induced DNA damage may play a role in the aging process in healthy individuals too. By pinpointing aldehydes as substances that contribute to aging, this study sheds light on the intricate connection between environmental factors and cellular aging. This may have significant implications for human health and lifespan.
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