Periodontal disease, represented by periodontitis, is the leading cause of tooth loss and affects close to one in five adults worldwide.
May 22 2024Tokyo Medical and Dental University In most cases, this condition occurs as a result of an inflammatory response to bacterial infection of the tissue around teeth. As the condition worsens, the gums begin to pull away, exposing teeth roots and bone. Notably, the incidence of periodontitis becomes more prevalent with age and with populations worldwide living longer, developing a solid understanding of its underlying causes and progression is important.
Studying periodontitis directly in humans is challenging. As a result, scientists often resort to animal models for preclinical research. For instance, the "mouse ligature-induced periodontitis model," since its inception in 2012, has enabled researchers to study the cellular mechanisms underlying this condition. Simply put, with this model, periodontal disease is artificially induced by ligating silk threads onto the molars of mice models, which induces plaque accumulation.
After confirming the efficacy of their modified model, the researchers proceeded to investigate the effects of periodontitis on gene expression among the different tissue types over time, focusing on genes related to inflammation and osteoclast differentiation. One of their main findings was that the expression of the Il1rl1 gene was markedly higher in peri-root tissue five days after ligation.
Periodontitis Bone Dentistry Gene Genes Inflammation Membrane Periodontal Disease Protein Receptor Research Teeth
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Clarifying the cellular mechanisms underlying periodontitis with an improved animal modelTokyo Medical and Dental University (TMDU) researchers have developed a technique that allows a detailed analysis of periodontitis development over time.
Read more »
Study shows boys' depressive symptoms rose with pandemic, but girls' improved during initial school closuresA study in the Journal of the American Academy of Child and Adolescent Psychiatry found that girls and boys were affected differently by the pandemic. The study focused on depressive symptoms among 16-year-olds surveyed during the pandemic compared to those surveyed pre-pandemic.
Read more »
Unlocking key answers on cell functioning for improved cancer treatmentsPeter Mac researchers have found the answer to a decades-long question on cell functioning that could lead to improved cancer treatments in the future.
Read more »
Jeff Stelling declares Newcastle United star is most improved Premier League player of the seasonThe Mag
Read more »
Rocco Vata and Daniel Kelly offered improved Celtic contractThe two talented youngsters have been offered bumper new deals to stay at Parkhead.
Read more »
Virtual medicine: How telehealth has improved the lives of people with substance disordersFrom the driver's seat of his parked truck, Lewis recalled what it felt like to take opioids.
Read more »