Improving Dolutegravir Delivery For Pediatric HIV Patients. SciReports nanomedicine AIDS nanoparticles nanotechnology
By Bhavna KavetiAug 23 2022Reviewed by Susha Cheriyedath, M.Sc. Dolutegravir is an antiretroviral drug used to treat human immunodeficiency virus in adults and children . However, this drug possesses solubility issues. An article published in Scientific Reports presented the fabrication of DTG-loaded chitosan nanoparticles with improved solubility and bioavailability.
Figure 1. The comparative HPLC chromatograms of Dolutegravir developed using a mixture of water, acetonitrile and methanol in the ratio of 20:40:40 with 0.2% formic acid as the mobile phase. System suitability; Dolutegravir with internal standard; low-level; mid-level; high-level of DTG concentrations. © K, P.D., D, R.D., S, B., Narayanan, H.B.
Generally, drug-loaded nanoparticle’s oral administration increases the cellular uptake, enhancing the exposure of the drug to plasma. Moreover, limiting the exposure of the drug to the enzymatic and non-enzymatic degradation in the gastrointestinal tract can enhance its bioavailability. Furthermore, the oral administration of a drug can increase cellular uptake and enhance the exposure of the drug to plasma. Moreover, loading the drug in nanoparticles reduces the susceptibility of the drug to enzymatic and non-enzymatic degradation in the GI tract. Thus, the present aim of increasing the bioavailability of the DTG drug was achieved by loading the drug into chitosan nanoparticles.
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