I am a scientist, businessman, author, and philanthropist. For nearly two decades, I was a professor at Harvard Medical School and Harvard School of Public Health where I founded two academic research departments, the Division of Biochemical Pharmacology and the Division of Human Retrovirology.
Alzheimer’s and heart disease are two of the leading causes of death, both affecting millions of people around the world. Now, increasing studies have found that brain and heart health may be more connected than initially thought. At the interface between brain cells and blood vessels, the blood-brain barrier endures damage with age that seems to contribute to worsening cognitive function.
What is white matter? Unlike gray matter which is comprised of neural cell bodies, white matter refers to the myelinated, or enclosed, axon fibers that facilitate the fast transmission of nerve impulses. White matter is essential for brain health and executing daily functions, including memory, problem-solving, and coordination.
To determine how blood-brain barrier dysfunction induces white matter changes in Alzheimer’s disease, Bagi et. al examined the brains of 28 people above the age of 65. This cohort included both men and women known to have Alzheimer’s disease, with or without obvious microvascular damage, in addition to healthy controls.
Heart Disease Cognition Dementia Blood Blood-Brain Barrier Cardiovascular
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