Researchers found that semaglutide treatment for weight loss in non-diabetic, obese men is associated with an increased risk of erectile dysfunction and testosterone deficiency.
By Hugo Francisco de SouzaMay 26 2024Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the IJIR: Your Sexual Medicine Journal, researchers assess the risk of erectile dysfunction in obese and non-diabetic men following semaglutide treatment.
Currently, semaglutide is considered one of the most effective anti-obesity interventions, with some scientists describing the United States Food and Drug Administration approval of this drug as a "paradigm shift" in anti-obesity treatment. In addition to its T2D and obesity benefits, semaglutide has been clinically validated to reduce the risk of cardiovascular disease, myocardial infarction, and strokes in obese men and women.
About the study In the present study, researchers assess sexual dysfunction risks associated with semaglutide use by non-diabetic and obese men. Study participants were recruited from the TriNetX, LLC Research Network, which includes electronic medical records, demographic details, and insurance claims for 118 million individuals across 81 healthcare organizations.
Related StoriesThe present study was almost exclusively statistical, with all statistical analyses carried out using the TriNetX platform. The univariate analysis involved the Chi-square test and T-test with between-group variation tested using propensity matching. Of the study participants who were prescribed semaglutide, 1.47% were diagnosed with ED or prescribed a phosphodiesterase 5 inhibitor , which is a class of drugs widely used in the management of ED. Comparatively, 0.32% of control patients were diagnosed with ED or prescribed PDE5Is. Moreover, 1.53% of cases were diagnosed with testosterone deficiency after being prescribed semaglutide as compared to 0.80% of men in the matched control group.
Semaglutide Diabetes Food GLP-1 Insulin Medicine Obesity Pancreas Research Sexual Dysfunction Testosterone Type 2 Diabetes Weight Loss
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