Increased serum homocysteine in first episode and drug-naïve individuals with schizophrenia: sex differences and correlations with clinical symptoms - BMC Psychiatry

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Increased serum homocysteine in first episode and drug-naïve individuals with schizophrenia: sex differences and correlations with clinical symptoms - BMC Psychiatry
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A study published in BMCPsychiatry finds that male first episode drug-naïve (FEDN) patients with schizophrenia have higher homocysteine levels than female FEDN patients and healthy controls.

]. First-episode drug-naïve individuals with schizophrenia are the optimal population to evaluate the relationships between Hcy and schizophrenia and clinical features, because of the absence of confounding factors such as medication, BMI, diet, and the stage of illness.

The present study therefore aimed to assess Hcy levels and its associations with clinical features in FEDN schizophrenia individuals of Chinese Han ethnicity. We hypothesized that Hcy levels may be altered and may be correlated with schizophrenia clinical features. The results showed whether serum Hcy levels differed between FEDN individuals with schizophrenia and healthy controls and whether there were associations between serum Hcy levels, sex, and BMI, and the severities of clinical symptoms.

Healthy controls were enrolled after responding to advertisements in Beijing. They were matched for sex, age, years of education, and BMI. Individuals were also evaluated for mental status using Axis I disorders. Candidates who met psychiatric disorders or a family history for psychiatric disorders were excluded.

The health status of each participant was identified by physical examinations and laboratory tests. Individuals with the following conditions were excluded: mental retardation, epilepsy, traumatic or chronic brain injury, diabetes, thyroid diseases, infections, cardiovascular and cerebrovascular diseases, pregnancy, and drug or alcohol abuse/dependence.

All subjects or their guardians gave informed written consent, and the research protocol was approved by the Ethics and Research Committee of Beijing Hui-Long-Guan Hospital.WE used an EDTA tube to collect venous blood samples from patients and healthy controls between 08:00 and 09:00 after overnight fasting.

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