Study identifies key inflammatory and immune response proteins linked to endometrial cancer risk through both observational and Mendelian Randomization analyses, revealing the roles of IL-6 and HSD11B1.
By Dr. Sanchari Sinha Dutta, Ph.D.Reviewed by Benedette Cuffari, M.Sc.Oct 1 2024 Discover how scientists have uncovered the links between inflammatory proteins and endometrial cancer risk, with IL-6 emerging as a potential target for future prevention and treatment strategies.
Inflammation and immune dysregulation, for example, are considered major contributors to endometrial carcinogenesis. Moreover, diseases characterized by chronic low-grade inflammation, such as obesity, are well-established risk factors for this type of cancer. Sensitivity analyses demonstrated that the inverse association between HSD11B1 and cancer risk was stronger in women with higher body mass index , suggesting that obesity may modify the impact of this biomarker on endometrial cancer risk.
The analysis of pre-diagnostic circulating biomarkers revealed that IL-6, hepatocyte growth factor , phosphoinositide 3-kinase adapter protein 1 , and C-type lectin domain family 4 member G are positively associated with endometrial cancer risk. Comparatively, hydroxysteroid 11-beta dehydrogenase 1 , Skp1/cullin/F-box protein , and chemokine ligand 25 are negatively or inversely associated with endometrial cancer risk.
Endometrial Cancer Carcinogenesis Chemokines Chronic CPR C-Reactive Protein Diagnostic Estrogen Genetic Glucocorticoid Immune Response Inflammation Interleukin Necrosis Obesity Proliferation Protein Receptor Tumor Tumor Necrosis Factor
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