Developing chemotherapy drugs against breast cancer is costly, slow, and often inefficient, with more than 95% of screened drug candidates failing in patient trials.
Aalto UniversityJun 14 2024 A groundbreaking technique for 3D cell culturing, developed by researchers at Finland's Aalto University, offers unprecedented insight into the spread of cancer cells through tissue. The technique paves the way to improved efficacy in screening for chemotherapy drug candidates, potentially enabling the screening out of non-viable drug candidates much earlier in the process.
Cancer cells actually feel the tissue that they're in, and they can change their behaviour based on their surroundings. When they move at different speeds they sense distinct stresses. Stresses can be the difference between the cancer spreading or its movement being mechanically blocked." After chemotherapy, residual cancer cells may remain in the tissue and start to move, causing the cancer to recur.
Related Stories"Our analysis allows us to take into account variations in the rigidity of tissue -; particularly the related "stiffness" -; and how this affects the way cancer cells grab and push and pull through the body, even following in each other's paths where there is less resistance," explains Pokki.
Biomechanics and drug resistance The innovation is particularly timely, given that recent studies show not only an important relationship between the biomechanical properties of the ECM and the spread of cancer cells, but also a relationship between tissue stiffness and drug resistance.
Breast Cancer Cell Cell Culture Chemotherapy Drugs Efficacy Research
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