Study demonstrates that a single-dose intranasal live-attenuated vaccine, CDO-7N-1, provides broad protection against SARS-CoV-2 and its variants by inducing potent immune responses, including neutralizing antibodies and T-cell activity, in animal models.
By Tarun Sai LomteReviewed by Benedette Cuffari, M.Sc.Sep 1 2024 Harnessing the power of a single dose, this innovative vaccine offers a potent defense against both current and future COVID-19 threats. Study: A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS -CoV-2 and its variants. Image Credit: Phonlamai Photo / Shutterstock.com
Therefore, it is crucial to develop novel vaccines that both induce broadly neutralizing antibodies and are effective against multiple variants, including those that may emerge in the future. LAVs induce potent and durable immune responses, often with a single dose. The immune response is antigenically broad because LAVs essentially contain the entire virus.
Related StoriesHamsters infected with CDO-7N-1 and CDO-4N-1 exhibited lower virus titers in bronchoalveolar lavage fluid than those infected with the WT virus. Furthermore, the lung pathology of animals infected with CDO-4N-1 was less severe than those infected with WT SARS-CoV-2, whereas little or no pathology was observed in those infected with CDO-7N-1.
After 28 days, control and vaccinated animals were challenged with WT SARS-CoV-2. Controls exhibited high virus titers in BALF and nose, in addition to prominent lung inflammation with mild/moderate olfactory epithelium atrophy. Comparatively, vaccinated animals did not have any detectable virus in their sera, exhibited no/slight lung inflammation, and maintained normal structure in the nasal turbinate.
Vaccine Antibodies Antibody CD4 Cell Codon Coronavirus Efficacy Immune Response Immunity Immunization Inflammation Lungs Omicron Pathology Protein Receptor Respiratory SARS SARS-Cov-2 Severe Acute Respiratory Severe Acute Respiratory Syndrome Spike Protein Syndrome Virus
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