This project aims to determine whether low doses of levetiracetam can improve episodic memory deficits in individuals with amnestic mild cognitive impairment (aMCI) in Parkinson's disease (PD). The study will investigate the feasibility of a trial to establish the efficacy of levetiracetam in targeting hyperactivation of hippocampal DG/CA3 subfields and improving memory performance. Participants will undergo a 12-week randomized, placebo-controlled, double-blind cross-over trial.
Mild memory impairment, termed amnestic mild cognitive impairment (aMCI), is associated with rapid progression towards dementia in Parkinson’s disease (PD). Studies have shown hyperactivation of hippocampal DG/CA3 subfields during an episodic memory task as a biomarker of aMCI related to Alzheimer’s disease.
This project investigates the feasibility of a trial to establish the efficacy of a repurposed antiepileptic drug, levetiracetam, in low doses as a putative treatment to target DG/CA3 hyperactivation and improve episodic memory deficits in aMCI in PD. Based on previous work, it is hypothesized that levetiracetam will normalize DG/CA3 overactivation in PD-aMCI participants and improve memory performance.Twenty-eight PD-aMCI participants, 28 PD participants without memory impairment (PD-nMI), and 28 healthy controls will be recruited. PD-aMCI participants will undertake a 12-week randomized, placebo-controlled, double-blind cross-over trial with a 14-day treatment of 125 mg levetiracetam or placebo twice daily, separated by a 4-week washout perio
Memory Impairment Parkinson's Disease Amnestic Mild Cognitive Impairment Levetiracetam Hippocampal DG/CA3 Subfields Episodic Memory Deficits Randomized Trial
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