Research investigates the association between irritable bowel syndrome (IBS) and Parkinson's disease (PD), revealing that IBS is not linked to an increased overall risk of PD. Subgroup analyses suggest that certain IBS populations may have a lower risk of developing PD.
By Pooja Toshniwal PahariaMar 31 2024Reviewed by Benedette Cuffari, M.Sc. In a recent study published in npj Parkinson's Disease, researchers explore the relationship between Parkinson's disease and irritable bowel syndrome .
The specific etiology of PD is unknown; however, the disease may caused by environmental and genetic factors. There is evidence linking PD to gastrointestinal symptoms, which might be related to changes in the gut microbiome, enhanced intestinal permeability, or gut-brain communication. Any individuals with missing data, as well as those with other neurological and gastrointestinal disorders, were excluded from the study. Likewise, any individuals diagnosed with PD before study initiation and those with indeterminate dates for IBS diagnosis were also excluded. Taken together, 26,944 individuals were diagnosed with PD and 2,460 with IBS using the International Classification of Disease-10 codes.
Study findings Of the 419,685 individuals involved in Cox modeling, 95% comprised the control study group, and 4.7% were diagnosed with IBS before study initiation. Both groups were monitored for a mean of 14 years. Subgroup analysis revealed that IBS was associated with a lower incidence of PD among white individuals, individuals with a smoking history, BMI between 25-29.90, and less than college-level educational attainment, with HRs of 0.8, 0.6, 0.6, and 0.8, respectively.
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