Is there radiographic evidence of premature brain aging in individuals with type 1 diabetes? JAMANetworkOpen UTHealthSA radiography premature brain aging type1diabetes T1D brainaging
By Neha MathurJun 6 2023Reviewed by Lily Ramsey, LLM In a recent article published in the JAMA Network Open, researchers identified brain regions most affected in middle-aged and older adults with type I diabetes to assess whether these structural changes reflected brain atrophy, i.e., loss of neurons and neuronal connections, commonly observed in neurodegenerative diseases, e.g., Alzheimer's disease .
About the study In the present study, researchers recruited participants from two cohort studies combined, the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications conducted at 27 clinical centers in the United States and Canada, to evaluate brain neuroimaging markers used to detect brain age and AD-like atrophy.
Related StoriesThe team evaluated psychomotor and mental efficiency using verbal fluency, trail-making part B, the grooved pegboard, and the digit symbol substitution test. They derived immediate memory scores from a subtest of the Wechsler memory scale-Wechsler digit symbol substitution test termed the logical memory.
Alongside, they obtained their detailed medical history, including demographics, medications, physical measurements [e.g., height, weight, body mass index , pulse rate, and blood pressure], and laboratory workup studies for fasting lipids, albumin excretion rate , hemoglobin A1c , and serum creatinine.
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