Oral treatment with Janus kinase (JAK) inhibitors demonstrated improved skin clearance in two phase 2b trial extensions, according to presentations at the annual meeting of the American Academy of Dermatology (AAD). The findings suggest that combining JAK inhibitors with phototherapy may be beneficial for patients. However, further investigation is needed due to the small sample size in the extension study.
In two different phase 2b trial extensions, oral treatment with Janus kinase (JAK) inhibitors showed improved skin clearance , according to presentations at a late-breaking session at the annual meeting of the American Academy of Dermatology (AAD).
Based on the ritlecitinib data, "if you have phototherapy in your office, it might be good to couple it with ritlecitinib for patients," said Emma Guttman-Yassky, MD, PhD, chair of the Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York City, who presented the findings. However, because of the relatively small numbers in the extension study, Guttman-Yassky characterized the evidence as preliminary and in need of further investigation. Phototherapy, which has been used for decades in the treatment of vitiligo, has an established efficacy and safety profile as a stand-alone vitiligo treatment
JAK Inhibitors Skin Clearance Phase 2B Trials Oral Treatment Phototherapy Vitiligo
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