As prostate cancer progresses, it becomes increasingly aggressive and can metastasise. In this form, the tumor is difficult to treat, which is reflected in high mortality rates: Worldwide, the malignant disease of the prostate is the second most common cause of cancer death in men.
Jun 5 2024Medical University of Vienna An international study led by Lukas Kenner and Sabine Lagger has now identified a protein that could slow tumor growth. The results, which have just been published in the top journal "Molecular Cancer ", provide a new starting point for the development of therapies.
The complex molecular processes that lead to the progression of prostate cancer have not yet been fully clarified by science. The protein known as JUN is being intensively researched as a possible driver of tumor growth. "Numerous studies have shown that JUN is produced excessively in cancer. So, a link has been established between tumor growth and high JUN levels," says Lukas Kenner , explaining the background to the current study.
The fact that JUN plays an important role in the activation of genes and various processes such as cell growth was discovered back in the 1980s. "In our investigations, we found that JUN is significantly involved in the regulation of prostate cancer by influencing the body's immune response," says Sabine Lagger from the Department of Laboratory Animal Pathology at Vetmeduni Vienna, explaining the connections currently being researched.
Most common cancer in men Prostate cancer has been the most common cancer in men in Austria for decades. Every year, around 6,000 new cases and 1,300 deaths are registered as a result of prostate cancer. In the vast majority of cases, tumors in the prostate gland remain localized and are therefore easily treatable. However, around 20 per cent of patients develop metastatic prostate cancer, which remains difficult to treat.
Prostate Prostate Cancer Protein Laboratory Malignant Mortality Pathology Research
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