Review highlights kaempferol's potential in treating triple-negative breast cancer through various anticancer mechanisms and improving chemotherapeutic efficacy.
By Dr. Sanchari Sinha Dutta, Ph.D.Jul 24 2024 In an article published in the journal Nutrients , authors at Florida A&M University summarized the latest research on the anticancer potential of kaempferol against triple-negative breast cancer .
Among various subtypes, triple-negative breast cancer is an aggressive phenotype accounting for about 10 – 15% of all breast cancer cases. The absence of estrogen, progesterone, and human epidermal growth receptors in TNBC makes it challenging to treat with standardized hormone therapy. All metabolites of kaempferol are absorbed into the systemic circulation, distributed in various tissues, and excreted in feces and urine.
The effect of the flavonoid kaempferol on the development and progression of breast cancer. Green arrows indicate induction and red arrows indicate inhibition. Evidence collected from 2D and 3D cell culture models indicates that kaempferol induces breast cancer cell apoptosis by modulating the ERK/MEK1/ELK1 signaling pathway.
Regarding antioxidant activity, evidence indicates that kaempferol inhibits the formation of neutrophil extracellular traps, reducing the production of reactive oxygen species and inhibiting breast cancer metastasis. Kaempferol has also been found to inhibit TNBC cell adhesion, motility, and migration by reducing the expression of matrix metalloproteinase-2 and MMP-9.
Cancer Antioxidant Apoptosis Cell Cell Proliferation DNA DNA Synthesis Enzyme Estrogen Flavonoid Genetic Hormone Liver Metabolism Nutrients Phenotype Progesterone Proliferation Radiation Exposure Receptor Research Vinblastine Vincristine
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