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keeping our bodies in sync internally and with the outside world – and two new studies show how these clocks combine to keep tissues functioning and to slow down the rate at which they age.If these mechanisms can be explored in more detail and controlled to some extent, then it could be a significant step towards keeping parts of the body in better health for longer as we get older.
"Our study reveals that minimal interaction between only two tissue clocks, one central and the other peripheral, is needed to maintain optimal functioning of tissues like muscles and skin and to avoid their deterioration and aging,", used experiments using mice to show how restoring the coordination between brain and muscle clocks protects against muscle wastage and loss of muscle strength and function., the team looked at the circadian clock in the skin of mice.
The peripheral clocks do have some autonomy though, the research found: they can still keep track of 24-hour cycles, and manage a small fraction of cell functions. What's more,of the mice to certain times of day in the absence of the brain clock was shown to help peripheral clocks to better manage on their own.
"It is fascinating to see how synchronization between the brain and peripheral circadian clocks plays a critical role in skin and muscle health, while peripheral clocks alone are autonomous in carrying out the most basic tissue functions,"that play out in our bodies across 24 hours are key to most biological processes, including sleep and digestion.
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