For the roughly 150,000 AIDS patients who come down with a life-threatening infection called fungal meningitis each year, there aren't many options.
May 9 2024Duke University For the roughly 150,000 AIDS patients who come down with a life-threatening infection called fungal meningitis each year, there aren't many options.
The same effects have yet to be shown in humans, the researchers caution. But the results, published April 15 in the journal mBio, could point to a simple way to make an essential medicine more effective, particularly in areas where no other alternatives exist. The shift put the keto-diet mice into ketosis: a metabolic state where the body burns fats for energy instead of glucose.
Within a week of starting treatment, fluconazole alone reduced the levels of fungi in the mice by roughly 10- to 100-fold. But when taken in combination with a keto diet, the drug dropped the mice's fungal levels by as much as ten thousandfold. The effects weren't restricted to Cryptococcus infections, either. The keto diet also made fluconazole more potent against another potentially life-threatening infection, caused when a yeast called Candida albicans enters the bloodstream.
This doesn't mean that the next time you get a toenail infection, you should try cutting carbs and filling up on fats while you take your meds, she added.
Diet AIDS Drugs Efficacy Fungal Infection Fungi Glucose Infectious Diseases Ketogenic Diet Medicine Meningitis Research Yeast
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