Researchers reviewed published scientific work on the kidney-gut axis.
By Neha MathurAug 22 2023Reviewed by Sophia Coveney In a recent article published in Nutrients, researchers reviewed published scientific work on the kidney-gut axis, defined as the bidirectional relationship between gut microbiota and chronic kidney disease , the impact of the microbiome dysbiosis on CKD and the current pharmacological and non-pharmacological therapeutic options for CKD treatment.
These inflammation-mediated aberrant metabolic processes trigger the overproduction of antibodies, immune complexes, and inflammatory factors, which directly/indirectly damage the renal parenchyma. Related StoriesSuch infants are born with a low number of nephrons, a condition referred to as low nephron endowment, which makes them prone to developing CKD and hypertension in later life. Early interventions and preventive strategies are, thus, crucial for normal kidney development.
Doctors commonly prescribe antibiotic therapy in neonatal and pediatric populations, which disrupts their intestinal microbiota. It enriches the reservoir of antibiotic-resistance genes, which get transferred to pathogens and make them antibiotic-resistant.
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